Yinyani eyaziwayo ukuba i-testosterone yihomoni yesini sendoda, kwaye i-estrogens (estron, estriol kunye ne-estrodiol) ngabasetyhini. Nangona kunjalo, umzimba wendoda uvelisa ixabiso elincinci le-estradiol, elibandakanyekayo kwiinkqubo ze-metabolic - kunye nomsebenzi wokuzala.
Kwangaxeshanye, ukonyuka kwamanqanaba e-estrogen ngokuqinisekileyo kuyingozi kwimetabolism yamadoda. Iimpawu eziqhelekileyo ziquka ipateni yokutyeba kwabasetyhini (kuquka i-gynecomastia), iingxaki zamandla, kunye nokuncipha kokukhula kumakhwenkwe afikisayo. Indlela yokunciphisa i-estrogen?
I-Estrogens kumzimba wendoda
Igama elithi "estrogens" ligama elidityanisiweyo leehomoni ezininzi. Eyona nto inamandla kwezi yi-estradiol, ilandelwa yi-estrone kunye ne-estriol. Ngokwakheka kwazo, ezi ziihomoni zesini ze-steroid ezinoxanduva lokulawula imisebenzi yebhayoloji yomzimba.
Kwabasetyhini, ziveliswa kwii-ovari kwaye zinefuthe elivakalayo lobufazi kuwo wonke umzimba. Emadodeni, ii-estrogens (kwimithamo emincinci kakhulu) yenziwa kumasende, i-adrenal cortex, ingqondo, amathambo kunye nezicubu ze-adipose - ezinefuthe lasekhaya ubukhulu becala.
Izinga lokuveliswa kwe-estrogen emzimbeni wendoda endala malunga ne-10-60 pg / ml ye-estrone kunye ne-10-40 pg / ml ye-estradiol enamandla ngakumbi. Ukuthelekisa, umzimba wesifazane uvelisa ukuya kuthi ga kwi-500 pg / ml ye-estrogens eyahlukeneyo ngaphambi kokuya esikhathini; emva kokufikelela kwiminyaka engama-50, akukho ngaphezu kwe-10-100 pg / ml.
I-Phytoestrogens ekutyeni
Okunye ukutya, okufana neembotyi zesoya kunye nebhiya, iqulethe i-phytoestrogens. Ezi zondlo ziiprotheyini ezinesakhiwo ezifana ne-estrogens. Nangona bekwazi ukuchaphazela i-receptors yomzimba efanayo njenge-estrogens eqhelekileyo, inqanaba le mpembelelo lilinganiselwe kakhulu.
Ngamanye amazwi, uphando alubonisi unxibelelwano phakathi kokutya izixa ezifanelekileyo zeemveliso zesoya okanye ibhiya kumanqanaba e-estrogen kumadoda asempilweni. Nangona kunjalo, uphando luyenziwa malunga nemiphumo emibi enokubakho ye-phytoestrogens kumzimba wolutsha.
Impembelelo kumsebenzi wokuzala
Impembelelo yebhalansi ye-estrogen kunye ne-testosterone kumsebenzi wokuzala wamadoda sisihloko esifundwa ngokukhutheleyo. Umzekelo, ngoJulayi ka-2020, idatha evela kuphononongo olubanzi yapapashwa ehlalutya impilo yezesondo yamadoda ayi-1076 aneminyaka eyi-19 ukuya kuma-60 yeminyaka¹.
Amadoda afundisiweyo anengxaki yolunye lweentlobo ezintathu zokungasebenzi kakuhle kwezesondo - iingxaki zokuqhama, ukuphuma kwangaphambi kwexesha kunye nobunzima bokufikelela kwi-ejaculation. Ngasinye kwezi ngxaki sibonakaliswa ngamanqanaba aphantsi okanye aphezulu e-estrogen.
Ngokomzekelo, ubunzima bokufikelela kwi-ejaculation budibene namanqanaba aphezulu ehomoni. Nangona kunjalo, iingxaki ngokwakhiwa zabonwa ngokuchasene nemvelaphi yokuncipha kwe-estrogen. Ekugqibeleni, i-ejaculation yangaphambi kwexesha ihambelana ne-estrogen eqhelekileyo kodwa i-testosterone ephakamileyo.
I-Estrogens emadodeni:
- inqanaba eliphantsi - iingxaki kunye ne-libido kunye nokwakhiwa
- izinga eliphezulu - ukulibaziseka kwi-ejaculation
Inzuzo okanye ingozi?
Olunye uphononongo lwafumanisa ukuba amanqanaba e-estrogen asezantsi (kwimeko yamanqanaba asezantsi e-testosterone) achaphazele kakubi i-libido, ngelixa ukonyuka kwamanqanaba e-estradiol egazi ukuya kuthi ga kwi-5 ng/dL kube nefuthe elihle kumsebenzi wokuzala wamadoda³.
Ngaphandle koku, sithetha ngamanani amancinci kakhulu e-estrogens - ngaphandle kwamathandabuzo, ukugqithisa kweehomoni zabasetyhini emzimbeni wendoda kuchaphazela kakubi ukusebenza kweenkqubo ezininzi. Kule meko, enye yeempawu eziphambili yi-gynecomastia - ukukhula kwezicubu ezinamafutha kwindawo yebele.
I-Estrogens kunye ne-gynecomastia
I-Gynecomastia sisifo esihambelana nokukhula kwezicubu ezinamafutha kwindawo yesifuba emadodeni ngokohlobo lwabasetyhini. Esinye sezizathu ze-gynecomastia ingaba yinqanaba elongeziweyo le-estrogen - ngakumbi ngokuchasene nemvelaphi yobunzima obuninzi kunye nokugcinwa kwamafutha e-visceral, echaphazela i-metabolism.
I-downside ye-gynecomastia kukuba xa ulahlekelwa ubunzima kwaye ulahla amanqatha, amabele awabuyeli kwisimo sawo esiqhelekileyo - nokuba kukho izihlunu. Kule meko, utyando lusetyenziswa, ngenxa yoko i-micro-incision yenziwa apho izicubu ezingaphezulu zisuswe.
Impembelelo ekukhuleni kolutsha
Phakathi kwezinye izinto, izixa ezigqithisileyo ze-estrogen kumzimba wamakhwenkwe akwishumi elivisayo kukhokelela ekubambeni ukukhula kwaye kuchaphazela kakubi i-testosterone. Indima enokwenzeka inokudlalwa, kwakhona, ngokubakho kobunzima obuninzi - kunye nobukho obuqhelekileyo bokutya kunye ne-phytoestrogens ekudleni.
Indlela yokunciphisa i-estrogen - isondlo
Enye yeendlela ezilula zokunciphisa amanqanaba e-estrogen emadodeni kukwenza umthambo rhoqo, ngakumbi ukuqeqeshwa kwamandla. Ukwandisa i-testosterone kuchaphazela inani leenkqubo emzimbeni, kubandakanywa ukuvutha kwamafutha, ukufumana ubunzima bemisipha - kunye nokunciphisa umphumo we-estrogen.
Ukongeza, izazinzulu zicebisa oku kutya kulandelayo:
- Imifuno eluhlaza. Sithetha ngazo zonke iintlobo zezityalo zesaladi (kubandakanywa i-arugula kunye ne-iceberg) kunye neentlobo ezahlukeneyo zeklabishi (iklabishi, i-broccoli, njl.) - ziqulethe i-phytonutrients evimbela ukuveliswa kwe-estrogen.
- Amakhowe - ngokwemvelo ukunciphisa umsebenzi we-enzyme ye-aromatase, edlala indima ebalulekileyo kwinkqubo yokuguqula i-androgens ibe yi-estrogens.
- Amazimba okusanhlamvu. I-Cereals (i-buckwheat, i-quinoa, i-spelt, i-oats) iqulethe i-fiber, ukusetyenziswa kwayo ineenzuzo ezininzi zempilo-kubandakanywa nokunciphisa i-estrogen.
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I-Estrogens ziihomoni zesini ze-steroid ezilawula umsebenzi wokuzala wemizimba yomibini yabasetyhini neyendoda. Kwangaxeshanye, amanqanaba aphantsi kakhulu e-estrogen emadodeni anxulunyaniswa nokuncipha kwe-libido, kwaye amanqanaba aphezulu kakhulu adityaniswa kungekuphela nje ngokufumana kwamafutha ohlobo lwabasetyhini, kodwa kunye nokungazali.
Imithombo yezenzululwazi:
umthombo: sukoku.ru
- Amanqanaba ahlukeneyo e-estradiol ahambelana nokungasebenzi kakuhle ngokwesondo kumadoda amadala. Fuente
- Finkelstein, J. S. okqhubekayo. I-Gonadal steroids kunye nokwakheka komzimba, amandla, kunye nomsebenzi wesondo emadodeni. N. Engl. J. Med.369, 1011-1022 (2013).
- Ramasamy, R., Kovac, JR, Scovell, JM & Lipsultz, LI Amagama obulumko. Impendulo: Kumadoda amadala i-testosterone ye-plasma efanelekileyo idibaniswa nokunciphisa konke okubangela ukufa kunye ne-dihydrotestosterone ephezulu kunye nokunciphisa ukufa kwesifo senhliziyo ye-ischemic, ngelixa amanqanaba e-estradiol awaqikeleli ukufa. I-eur. Urol.65, 844 (2014).
- Imiba yoMngcipheko wokuba namaNqanaba e-Estrogen aPhakamileyo okanye aPhantsi kuMadoda. Umnxeba wezempilo